Jose Bautista (vertical) Jay Alou, Bautistas agent, has said that his client is open to a move to left field or the infield, which should help Bautistas market. National League teams without the luxury of a DH spot, however, may be wary about signing a player entering his age-36 season without any guarantee that he can provide passable defense. find more infoBautista has only played 154 MLB innings as a first baseman and 410 innings as a left fielder; a return to third base would seem very unlikely at this stage of his career. Beyond this seasons two DL trips, Bautista was also limited to 92 games in 2012 due to a bad wrist that required post-season surgery, and 118 games in 2013 due to a bruised hip that prematurely ended his season. (In fairness to Bautista, both shutdowns were more than a little due to Toronto being miles out of the pennant race.) He also battled a bad shoulder in 2015 that required him to receive more DH at-bats than usual, though that injury didnt appear to impact his offensive production whatsoever. Personal Originally a 20th-round pick for the Pirates in the 2000 draft, Bautistas rise from journeyman to superstar is one of baseballs more unlikely breakout stories. He played for five different organizations in the 2004 season (his rookie year) before settling back in Pittsburgh and posting middling numbers in semi-regular duty as a third baseman and outfielder. Dealt to the Blue Jays in August 2008 for catcher Robinzon Diaz , Bautista still didnt entirely break out until a swing overhaul under the tutelage of Toronto manager Cito Gaston and hitting coach Dwayne Murphy. The results were incredible after managing just 59 career homers over his first 2038 PA in the bigs, Bautista exploded for 54 homers in 2010 and the rest is history. Bautistas outspoken personality made him a clubhouse leader in Toronto but also ruffled some feathers around the league, whether its questioning the strike zones of several umpires, getting involved in the most memorable on-field brawl in recent memory or his iconic bat flip home run in Game Five of the 2015 ALDS. There hasnt been any indication that Bautistas attitude is necessarily impacting his free agent stock; if anything, Bautista has a reputation as an intense competitor. Market Needless to say, Bautista wont be getting anything close to the massive asking price (five or six years for $150-$180MM) he reportedly floated during preseason extension talks with the Jays. In fact, given his disappointing year, Bautista couldve been justified in accepting the one-year, $17.2MM qualifying offer in the hopes of rebounding in 2017 and testing the market again next winter in search of a bigger contract. Instead, he rejected the Blue Jays offer, so any club that signs him will have to give up its top unprotected draft pickfor Bautistas services. As weve seen in the past, the qualifying offer can limit the market for anything less than superstar free agents. Between the draft pick compensation, Bautistas age, his declining defense and hitting numbers and the number of other first base/DH types on the market, Bautista could have a tough time finding what he believes is fair value. On the other hand, its hard to ignore Bautistas performance prior to 2016. There will certainly be teams interested in seeing if Bautista can bounce back to his old form, and Bautistas apparent willingness to shift out of right field will increase his list of suitors. Teams like the Orioles, Red Sox, Astros or Mariners have multiple holes at DH, first base or the corner outfield slots that Bautista could fill, switching positions on a near-daily basis to accommodate other players on the roster. The Dodgers, and Giants have corner outfield slots that Bautista could fill, and conceivably the As and Phillies could be added to the list if Bautistas price drops or if he isnt set on joining a contender. The Rockies could sign Bautista as a first baseman with an eye towards giving him some time in the outfield if Carlos Gonzalez or Charlie Blackmon are traded. The Nationals somewhat surprisingly asked about Bautista at last summers trade deadline so they could be a suitor now; with Ryan Zimmerman still holding down first base in Washington, Bautista would have to play right, with Harper sliding to center. I dont know if the bad blood between Bautista and the Rangers would preclude the two sides from doing business, though Bautista is at least an on-paper fitin Texas as a first baseman or designated hitter. The Yankees and Mets have both already been linked to Bautista, though the Mets would need to deal one of Lucas Duda , Jay Bruce , Curtis Granderson or (less likely) Michael Conforto to make room. For the Yankees, Bautista would add veteran stability to their young first base/right field/DH mix of Greg Bird , Tyler Austin , Aaron Judge and Aaron Hicks , and left field could also open up if anything comes of trade inquiries about Brett Gardner . While Blue Jays GM Ross Atkins recently said that the clubs signing of Kendrys Morales didnt mean that Toronto couldnt still bring back Bautista or Edwin Encarnacion , talks between Bautista and the Jays are reportedly not showing any signs of re-opening. Bautista could still technically fit playing right, first base and DH in rotation with Morales and Justin Smoak , though at this point, it seems like the Bautista era is Toronto is coming to a close. Expected Contract MLBTRs Tim Dierkes ranked Bautista 12th on his list of the offseasons top 50 free agents, projecting Bautista for a three-year, $51MM contract but with the potential for an opt-out clause after the first year or perhaps just a one-year deal altogether.

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Ibuprofen overdose is equally damaging and in no way beneficial to the health. Your health is something you shouldn’t even think of postponing care of as it could have dangerous consequences. One of the causes of colitis is the overgrowth of infectious agents. The vasculitis syndrome can be categorized into primary and secondary vasculitis. Sprinkle some sea salt in it and take a hot compress. There are three very powerful anthocyanins, which help in the prevention of inflammation. Chronic non-bacterial infections are characterized by pain in the genital areas and an increased frequency of urination. Besides containing nasty additives, these foods contain preservatives that may damage health. It is important that you also avoid any artificial sugar sweeteners. ✔ You can instead go for the natural sugar sources. If the problem is mild, one could just think of resting, taking anti-inflammatory medication or applying ice to the affected area to obtain relief.

It will allow 3P Biopharmaceuticals to contribute to a very innovative therapeutic approach, with our strong competence in the field of manufacturing high quality protein. _____________________________ 1IFN Kinoid: Therapeutic vaccine from Neovacs technology, which is composed of the targeted cytokine IFN, conjugated with a carrier protein, Keyhole Limpet Hemocyanin. About 3P Biopharmaceuticals 3P Biopharmaceuticals is a leading European CDMO specialized in the process development and GMP manufacturing of biologics and cell therapy products in mammalian, microbial and yeast expression systems. With a highly qualified team of experts, 3P supports its clients offering manufacturing related drug development solutions from initial research, through preclinical and clinical trials to commercialization. 3P was created and promoted by a group of shareholders and institutions with large expertise in the biotechnology and pharmaceutical sector. Thanks to their financial effort and full confidence, 3P has been able to consolidate its activity into the international market and has become a reference for the biotech sector. About Neovacs Technology Neovacs targets pathologies associated with an overproduction of endogenous cytokines. This technology is based on active immunotherapy to generate an immune response through the administration of an immunogenic complex involving the target cytokine to a carrier protein. The intramuscular injection of this Kinoid induces an immune response and stimulates the production of polyclonal antibodies against the target cytokines. It is thus possible to block cytokine overproduction and its biological effects. Several autoimmune and inflammatory diseases (Type 1 diabetes, systemic lupus erythematosus, psoriasis, etc.) are characterized by a disorder ofcytokines that are found produced in excess (ex: IFN). This overproduction will promote inflammation and dysregulation of the immune system.

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